bioRxiv 预印本· Castro-Cordova, P., Mendoza-Leon, M., Alamos-Musre, S., Munoz-Miralles, J., Diaz-Yanez, F., Marchant-Llancalahuen, F., Cea, D., Hernandez-Armengol, R., Valeria, J., Mondaca, K., Otero, C., Gil, F., Pizarro-Guajardo, M., Paredes-Sabja, D. ·· 21 小时前AI 评分30
制霉菌素联合牛磺胆酸靶向胞内艰难梭菌芽孢持续，降低复发感染
Repurposing nystatin and taurocholate to target intracellular spore persistence during antibiotic treatment to prevent recurrent Clostridioides difficile infection.
AI 导读
制霉菌素与牛磺胆酸联合抗生素经口给药，在小鼠模型中把原发性艰难梭菌感染后的复发率从100%降至44%；用于活动性复发性CDI时，二次复发率从100%降至62%。将制霉菌素与万古霉素包封于壳聚糖纳米粒后，复发定植率分别降至44%和33%，而游离万古霉素组为100%。
来源：bioRxiv 预印本 · biorxiv.org