Cell· Chaojie Wang, Xiaojie Zheng, Yunfa Zhang, Xing Shang, Qiaoqiao Qu, Chang Li, Xiaoai Zhang, Ningyi Jin, Wei Liu, Hao Li·· 2026-07-29AI 评分22
Gasdermin E 介导病毒性细胞焦亡与致死性肝脏脂质蓄积
Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation
AI 导读
Wetland virus 激活双重凋亡级联，触发 GSDME 依赖性肝细胞焦亡，进而重编程细胞脂质代谢，最终导致严重肝脂肪变性。靶向该焦亡-代谢轴可减轻小鼠致死性 Wetland virus 感染。
来源：Cell · cell.com