一项 remarkable 研究，对来自8个队列的1200万个单细胞（RNAseq）结合蛋白质组学进行分析，以确定与健康衰老相关的免疫细胞。主要发现包括： ——胸腺退化是核心（初始T细胞和胸腺迁出细胞减少） ——免疫系统激活升高，炎性衰老 ——CD8+记忆细胞（GZMB+）高频出现 ——CMV血清阳性与慢性疾病 @ImmunityCP 由 @maxim_artyomov 及同事发表 https://www.cell.com/immunity/fulltext/S1074-7613(26)00387-0
A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
https://www.cell.com/immunity/fulltext/S1074-7613(26)00387-0
来源：Eric Topol · x.com