medRxiv 预印本· Langton, D., Bhalekar, R., Borikar, Y., Wells, S., Clement, N., Deehan, D., Guest, D., Harrington, C., Jameson, S., Leitch, G., McManus, R., Pabbruwe, M., Phillips, J., Rushton, S., Porteous, A., Santini, A., Tross, S., Sidaginamale, R. ·· 21 小时前AI 评分22
HLA 基因型与钴铬膝关节置换患者报告结局及金属碎屑不良反应相关
HLA Genotype is Associated with Patient Reported Outcomes and Adverse Reactions to Metal Debris in Patients with Cobalt-Chrome Knee Arthroplasties
AI 导读
一项多中心前瞻性研究纳入376例钴铬膝关节置换患者，发现CoGR评分每升高1个单位，Forgotten Joint Score降低9.8分（95% CI 4.2-15.4，p<0.001）；血钴高于中位水平者降幅达17.5分。在28例ARMD（含12例ALVAL）与177例对照的病例对照分析中，CoGR每升高1个单位，ARMD和ALVAL的比值比分别为1.90和3.05。
来源：medRxiv 预印本 · medrxiv.org