bioRxiv 预印本· Jiang, Y., Bach, F., Houck, J., Carlson, M., Mahamar, A., Gaoussou, S., Attaher, O., Morrison, R., Kumar, S., Armistead, B., Zaidi, I., Kappe, S., Dicko, A., Duffy, P., Fried, M., Pepper, M., Harrington, W. E. ·· 17 小时前AI 评分20
母体微嵌合影响胎儿对恶性疟原虫的产前免疫致敏及疟疾结局
Prenatal immune priming to Plasmodium falciparum is characterized by multi-lineage T-cell responses that are influenced by maternal microchimerism and predict malaria outcomes
AI 导读
对97名马里初产妇的脐带血分析显示，母体微嵌合（MMc）与胎儿对恶性疟原虫（Pf）的产前免疫致敏（PIP）的数量和质量密切相关。MMc阳性婴儿的Pf反应性T细胞显著更少，ZBTB16+ CD4和细胞毒性Vγ9Vδ2+ γδ T细胞比例降低。临床上MMc与疟原虫血症和发热性疟疾风险降低相关，而ZBTB16+ CD4和活化CD4 T细胞频率则与风险升高相关。
来源：bioRxiv 预印本 · biorxiv.org