bioRxiv 预印本· Roth, A., Ali Asgari, M., Chandra, P., Muhammad, J., Lopez, A., Bhattacharya, S., Williams, I. A., Edelson, B., Goss, C. W., Kotov, D. I., Qian, M., Covey, D. F., Jiang, X., Griffiths, W. J., Wang, Y., Philips, J. A. ·· 1 天前AI 评分32
结核分枝杆菌通过3β-Hsd酶灭活宿主氧固醇，破坏巨噬细胞胆固醇稳态
Mycobacterium tuberculosis inactivates host oxysterols to impair macrophage cholesterol homeostasis
AI 导读
结核分枝杆菌（Mtb）通过其3β-羟基类固醇脱氢酶（3β-Hsd）将宿主内源性氧固醇27-HC和3β-HCA氧化为3-oxo-Δ4代谢物27-HCO和3O-CA，从而使其失去激活LXR和抑制SREBP2靶基因的功能。
来源：bioRxiv 预印本 · biorxiv.org