Cell· Raajaram Gowrishankar, Madelyn M. Hjort, Abigail J. Elerding, Sofia E. Shirley, Pranav Senthilkumar, Josie Van Tilburg, David J. Marcus, Khalid A. Abrera, Dustin Sumarli, Marcelina Wezik, Kat Motovilov, Adam G. Gordon, Zhe C. Zhou, Chunyang Dong, Lin Tian, Garret D. Stuber, Michael R. Bruchas·· 2026-08-31AI 评分18
背侧纹状体内源性阿片肽动态调控神经活动以促进目标导向行为
Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action
AI 导读
背侧内侧纹状体中，阿片类神经肽强啡肽（dynorphin）按细胞类型特异性、时间锁定方式释放，是目标导向行为的必要且充分条件。来自基底外侧杏仁核的输入触发强啡肽释放，通过kappa阿片受体介导逆行性Gi偶联突触前抑制，揭示了一种快速神经肽机制来塑造行为。
来源：Cell · cell.com