bioRxiv 预印本· Rawish, E., Rusack, T., Letsch, P. R., Inderhees, J., Haendler, K., Gragoll, C., Voran, J. C., Schneider, M., Kurz, K., Hosen, M. R., Behrensen, M., Denker, S., Kuenstner, A., Sauer, T., Duque-Escobar, J., Schmidt, T., Frank, D., Stiermaier, T., Raasch, W., Mueller, O. J., Zeller, T., Busch, H. S., Gemoll, T., Knosalla, C., Spielmann, M., Aherrharou, Z., Summers, S. A., Eitel, I., Frerker, C. ·· 16 小时前AI 评分22
神经酰胺驱动脂毒性经 ER-Stress-NF-κB-EndMT 信号促进钙化性主动脉瓣疾病，抑制 SPT 具治疗潜力
Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition
AI 导读
钙化性主动脉瓣疾病（CAVD）缺乏改善病情的疗法，研究整合人钙化与非钙化主动脉瓣的脂质组学与蛋白质组学，发现长链神经酰胺富集并与 NF-κB、EndMT 及 ER 应激/UPR 程序相关，而匹配血浆鞘脂未见升高。
来源：bioRxiv 预印本 · biorxiv.org