bioRxiv 预印本· Kockelbergh, H., Astley, J., Kichula, K. M., Zhang, Z., Ng, E. S., COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium,, Dendrou, C. A., Chong, A. Y., Watson, R. A., Fairfax, B. P., Knight, J. C., Band, G., Norman, P. J., Carrington, M. N., Sansom, S. N., Mentzer, A. J., Jostins-Dean, L., Luo, Y. ·· 1 天前AI 评分22
scTAPAS：从scRNA-seq重建供体基因型用于eQTL与HLA-TCR分析
Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA-TCR analysis
AI 导读
研究人员提出生物信息学框架scTAPAS，可直接从单细胞RNA测序reads重建供体基因型并用于下游遗传分析。将其应用于COMBAT的5' scRNA-seq数据，仅检测常规芯片分型可得变异的18.0%，却恢复了68.6%的细胞类型-eGene对，效应量高度一致。
来源：bioRxiv 预印本 · biorxiv.org