bioRxiv 预印本· Tengvall, K., Sohrab, V., Christmas, M. J., Brander, G., Pederson, E., Pensch, R., Kenney, B., Song, C., Wallerman, O., Sundstrom, E., Wang, C., Karlsson, A., Monsen, L. L., Nordic OCD and Related Disorders Consortium (NORDiC),, PGC TS/OCD working group,, Lord, K. A., Strom, N. I., Ruck, C., Mataix-Cols, D., Mattheisen, M., Crowley, J. J., Meadows, J. R. S., Karlsson, E., Lindblad-Toh, K. ·· 1 天前AI 评分22
犬-人基因网络共定位研究将突触信号与泛素化关联至强迫症
Dog-human gene network colocalization links synaptic signalling and ubiquitination to compulsive disorders
AI 导读
一项结合犬强迫症（dogCD）与人类强迫症（OCD）GWAS的跨物种分析，识别出165个基因组成的网络，该网络在当前人类样本量下无法检出。dogCD每个位点解释的表型方差至少是人类OCD位点的40倍，其风险变异主要为非编码调控变异，富集于犬脑八个区域的候选顺式调控元件。
来源：bioRxiv 预印本 · biorxiv.org