medRxiv 预印本· Small, A., Xue, L., Ito, S., De Jeronimo Diaz, C., Nakamura, Y., Mohammadnia, N., Liao, H., Maekawa, Y., Li, L., Singh, S. A., Kasai, T., Weiss, L., Uddin, M. M., Schuermans, A., Flynn, S., Mackenzie, E., Engert, J. C., Thanassoulis, G., Libby, P., Shah, A., Ballantyne, C. M., Natarajan, P., Fidler, T., Aikawa, E., Honigberg, M. C. ·· 2 天前AI 评分40
ASXL1 突变克隆性造血与钙化性主动脉瓣疾病相关，并在体外促进瓣膜钙化
ASXL1-Mutant Clonal Hematopoiesis is Associated with Calcific Aortic Valve Disease and Promotes Valvular Calcification In Vitro
AI 导读
基于 UK Biobank 449,109 例全外显子测序数据，大型 CHIP 克隆及非 DNMT3A 亚型（TET2、ASXL1、JAK2）与主动脉瓣狭窄发病风险独立相关；在 ARIC 研究 1,963 例中，仅 ASXL1 CHIP 与更差的主动脉瓣血流动力学相关。
来源：medRxiv 预印本 · medrxiv.org