bioRxiv 预印本· Gujar, H., Hanache, S., Aggarwal, S. ·· 1 天前AI 评分22
HPV阴性口腔癌中肿瘤相关巨噬细胞的年龄相关转录程序与肿瘤进展相关
Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer
AI 导读
研究者重新分析19例HPV阴性口腔鳞癌(OSCC)的单细胞RNA-seq数据,发现衰老与吸烟暴露共同驱动SPP1high肿瘤相关巨噬细胞(TAM)扩增,肿瘤微环境向髓系主导、淋巴细胞减少转变。
来源:bioRxiv 预印本 · biorxiv.org