The Lancet· Michael D Jenkinson, Anna Rosala-Hallas, Felix Sahm, Nicolaus Andratschke, Keyoumars Ashkan, Damiano Balestrini, Helen Bulbeck, Sílvia Comas, Giovanna Culeddu, Kumar Das, Laura Fariselli, Karen Foweraker, Priya Francis, Efstathia Gkioni, Vassilis Golfinopoulos, Thierry Gorlia, Neda Haghighi, Brian J Haylock, Dyfrig A Hughes, Mohsen Javadpour, Philippe Martinive, Helen M O Mayles, Perry Moore, Emilie Le Rhun, Nicola Rosenfelder, Gail Ryan, Michael Weller, Carrol Gamble, Matthias Preusser, Damien C Weber, ROAM/1308 Study Collaborators·· 14 天前精选AI 评分60
ROAM/EORTC-1308 III期试验：WHO 2级非典型脑膜瘤完全切除后放疗与观察对比
[Articles] Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, phase 3, randomised controlled trial
AI 导读
ROAM/EORTC-1308 国际多中心、开放标签、III期随机对照试验比较了 WHO 2 级非典型脑膜瘤完全手术切除后辅助放疗与观察。研究结果提示，当患者更看重预防复发、而非放疗可能带来的迟发不良反应时，应考虑辅助放疗，这一做法可通过减少脑膜瘤复发使患者获益。具体决策应基于与患者的个体化讨论。
推荐理由
原文给出非典型脑膜瘤术后放疗与观察的头对头III期结论，读者可据此理解复发预防与放疗迟发不良反应之间的权衡。
来源：The Lancet · thelancet.com