疫苗学家Peter Hotez表示，Y. pestis的F1和V蛋白是可靠靶点，Baylor-Texas Children's Hospital的mRNA技术已成熟，开发鼠疫疫苗不存在太多技术障碍。目前美国无鼠疫疫苗可用，俄罗斯仍在使用有问题的旧版减毒活疫苗。他认为只有美国政府可能支持mRNA鼠疫疫苗开发，但短期内不太可能实现。
I don’t think it would be complicated to develop a plague vaccine, both the Y. pestis F1 and V proteins look like solid targets and now that our Baylor-Texas Children’s Hospital scientists have advanced mRNA technology, I don’t see a lot of technical roadblocks. Right now there’s no plague vaccine available in the U.S., the Russians use an older live attenuated vaccine that has problems, but they’re still at an advantage. I doubt anyone but the U.S. Govt would support mRNA plague vaccine development, and I don’t see that happening anytime soon…
1/ We can treat plague with antibiotics. But can we vaccinate against Yersinia pestis? The answer is more interesting than simply “no.” Older plague vaccines still exist in limited settings. Several modern candidates have reached human trials. And newer RNA and viral-vector approaches are coming behind them. So where are we in 2026?在 X 查看被引用的帖子
来源：Prof Peter Hotez MD PhD DSc(hon) · x.com