Cell· Raleigh M. Linville, Benjamin T. James, Kyriaki Galani, Li-Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B. Fass, James C. Cameron, Brent E. Fitzwalter, Roland Bock, Erin M. Murray, Mathilde Louçã, Oluwamayowa Oke, Charlotte Wang, Erica Engelberg-Cook, Michael DeTure, Vanessa Farrell, Sergio Sebastian Pineda, Suphinya Sathitloetsakun, Xinyue Liang, Bertha Madras, Dennis W. Dickson, Deborah C. Mash, Gustavo Turecki, Vanessa C. Wheeler, Veronica A. Alvarez, Dana Gabuzda, Manolis Kellis, Myriam Heiman·· 2026-09-01AI 评分22
跨物种纹状体单细胞图谱揭示细胞类型与亚区疾病易感性
Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities
AI 导读
研究通过单核RNA测序与空间验证，构建了人类和小鼠纹状体的跨物种单细胞图谱，定义了神经元在细胞类型、亚区及物种间的特化规律。该图谱为理解成瘾风险、抗精神病药物反应、亨廷顿病易感性以及药理学相关物种差异提供了细胞和亚区层面的基础。
来源：Cell · cell.com